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GIPR and GLP-1R are widely expressed in various cells of the central nervous system (CNS), adipose tissue, kidney, and cardiovascular and hematopoietic systems, and therefore, effective anti-obesity treatments may have beneficial outcomes beyond reducing obesity (8)

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Adding cagrilintide to semaglutide enhances weight loss through an additional amylin receptor mechanism

14(8):10315 Klein S, Ghosh A, Cremieux PY, Eapen S, McGavock TJ (2011) Economic impact of the clinical benefits of bariatric surgery in diabetes patients with BMI 35 kg/m 2

It has recently been shown that a PEGylated GLP-1R/GcgR co-agonist could restore leptin sensitivity in DIO mice chronically maintained on a high-fat diet [73], and this may constitute one of the inherent weight-lowering actions of the co-agonist