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NASO B12 NASAL SPRAY is not recommended for use in patients allergic to mecobalamin, cobalt, and/or vitamin B12

age-related plasma decline (roughly 200 ng/mL at age 20 to about 80 ng/mL by 60): Pickart L, Margolina A

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It helps optimize energy use and reduces oxidative stress in cardiac tissue

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk