Treatment of newborn rats with L-buthionine sulfoximine (BSO), an irreversible inhibitor of GCLC, leads to hepatic abnormalities including mitochondrial dysfunction 10
Instead of simply appending a non-a-amino long straight chain amino acid to the N-terminal we chose to eliminate the N-terminal amine entirely, which increased overall hydrophobicity and removed a critical hydrogen bonding site
The second athlete is back on the field in half the time, stronger than before
The typical treatment length is 46 weeks based on provider recommendations and patient needs
The treatment normalized neurotransmitter levels (norepinephrine, dopamine, serotonin), highlighting its potential in ameliorating AD-like symptoms ( In vivo , HJG shortened swim times in the Morris Water Maze and increased phosphorylated CREB levels in A-injected Wistar rats, demonstrating its neuroprotective potential (Kubota et al., 2017)