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After oral administration of a 100 mg dose to healthy subjects, sitagliptin was rapidly absorbed, with peak plasma concentrations (median Tmax) occurring 1 to 4 hours postdose

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[1] [5] Risk factors for more severe constipation include pre-existing bowel conditions, inadequate fluid intake, low dietary fibre, reduced physical activity, and concurrent use of other constipating medications such as opioids or certain antidepressants

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