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Poor sleep increases inflammatory cytokines, shifts the Th1/Th2 balance toward Th2 (pro-allergic), and impairs regulatory T-cell function
This makes it harder for the B12 to break free and be absorbed by the body
Many vegetables/fruits contain carotenes, which are enzymatically hydrolyzed into retinal and converted to retinol, as are a few xanthines
More researches are still required to answer the temporal modulation, mechanisms of molecular and signaling pathways, and consequences of the BBB leakage in diabetes
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