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In addition, some researchers have used immunotherapy and synthetic biology to design living bacteria, combining immunotherapy expression with optimized lysis mechanism, so that living bacteria can carry nanobodies back to the core of necrotic tumors, grow to a critical density, and lyse, effectively and continuously releasing therapeutic drugs in the tumor microenvironment

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Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM

IGF-1 non-response occurs in approximately 5% of research models due to GH receptor polymorphisms or hepatic IGF-1 synthesis impairment