Santollo J, Daniels D
Potential Negative Effects on Mental Health While the potential benefits are encouraging, its crucial to acknowledge the potential negative impacts of GLP-1 inhibitors on mental health: Increased Anxiety and Agitation: Paradoxically, while some studies suggest anxiety reduction, others have reported instances of increased anxiety, restlessness, and agitation in individuals taking GLP-1 agonists
Long-Acting Amylin Agonist GUB014295 Gubra A/S (Hrsholm, Denmark), a biotech company specialized in pre-clinical contract research, initiated a phase 1 clinical trial (NCT06144684) to investigate the safety, tolerability and pharmacological properties of GUB014295 (GUBamy), a long-acting OW SC amylin agonist, in healthy volunteers [117]
Blher M, Rosenstock J, Hoefler J, Manuel R, Hennige AM
The majority of the reported events occurred in patients who had experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea [see Adverse Reactions (6.1)]