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Given the prevalence of cardiovascular disease, type 2 diabetes, chronic kidney disease, and metabolic syndrome, it seems plausible that GLP1s reduce all-cause mortality

The 5 mg dose is the lowest dose any Phase 3 trial has tested as long-term maintenance therapy

Even with careful engineering of receptor balance, potency and pharmacokinetics, problems may still crop up, as illustrated by SAR425899s unexpected development failure due to excessive gastrointestinal adverse events during its Phase 2 trials

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Taste and add honey or maple syrup if extra sweetness is needed