The study showed that compared with non-targeted liposomes (Lip-EXT), the cellular uptake rate of Apt-Lip-EXT was increased by approximately 97%, the in vitro transport efficiency was increased by approximately 95%, and absorption in small intestinal Peyers patches was significantly enhanced, indicating that aptamer modification can effectively promote M cell-mediated transport and targeted delivery of liposomes ( 2.3 Small-molecule ligand modification In oral liposome delivery systems, to overcome GI barriers and improve drug absorption efficiency, researchers have widely used small-molecule active substances as targeting ligands to modify the liposome surface for active targeting
The separation gradient was run with 2% to 5% B over 1 minute, 5% to 10% B over 9 minutes, 10% to 20% B over for 27 minutes, 20% to 35% B over 10 minutes, 35% B to 99% B over 10 minutes, a 2 minute hold at 99% B, and finally 99% B to 2% B held at 2% B for 5 minutes 17
M., Gratzl, S., et al (2024) Semaglutide vs
10.1002/1873-3468.12902 232 SteinerJ
and Donohoe, R
