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The reversal of NET function results in efflux of cytoplasmic norepinephrine, normally contained in the , readily releasable pool 12) into the synaptic cleft, independent of calcium influx and the normal process of vesicular release (Raiteri and Levi, 1986

In addition to the tumor matrix, a complex interplay between immune cells and tumor amino acid metabolism is emerging

225 Znrf3 inactivation mutations have been found in pancreatic cancer 226 and adrenocortical carcinoma, 227 but relatively few studies have examined the role of Znrf3 inactivation mutations in tumours

Science 372 , eabf1230 (2021)

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