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Estas modificaciones estructurales prolongan su actividad biolgica en comparacin con el IGF-1 nativo

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doi:10.1523/JNEUROSCI.1910-15.2015 Increased tissue concentrations of lactate stemming from localised mitochondrial dysfunction also promote a local inflammatory environment through triggering the release of cytokines IL-1B and TNF-a, along with increasing NF-KB-dependent inflammatory gene expression