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In addition, CP exposure also induced PTEN-induced kinase protein 1 (PINK1) and Parkin, the two mediators of mitochondrial autophagy that were recently involved in CP nephrotoxicity

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The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis

The heart may start to beat faster to make up for the reduced number of RBCs in the body