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However, there is an important consideration: in animal studies, high doses of GLP-1 receptor agonists, including semaglutide, were associated with thyroid tumors

Inflammatory mediators Tissue injury, however minor, initiates a localised inflammatory cascade involving histamine, prostaglandins, and cytokines, which sensitise nerve endings and cause the characteristic burning or stinging sensation

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To turn this mechanistic insight into a targeted therapy, we developed cartilage-targeting silk fibroin nanoparticles modified with a type II collagen-binding peptide WYRGRL for localized GLP-1RAs delivery (GLP-1RAs@NPs-WYRGRL)