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SFN is also shown to reduce proteolytic stress by decreasing MMP-9 expression and preserving BBB, and it also elevates the concentration of anti-inflammatory cytokine IL-10 in experimental autoimmune encephalomyelitis in C57BL/6 mice (88)
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We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion
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