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In a meta-analysis, a random-effects model estimated the overall hazard ratios for MACE and its components, such as death from any causes, HF-related hospital admissions, and crucial safety outcomes (severe hypoglycemia, pancreatitis, and pancreatic cancer), and showed beneficial effects with GLP-1 RAs on CV outcomes [60]

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In the current study, we showed that exendin-4 attenuates cocaine seeking and blocks cocaine seeking-evoked increases in VTA dopamine activity

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When compared with LDN, GLP-1 agonists present a distinct mechanism of action with potential synergistic effects onhealthspan extension