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Results Across mechanistic endpoints, LC was associated with reductions in inflammatory markers, oxidative stress indices, and cardiac injury biomarkers, with several trials noting improvements in left-ventricular function and lipid profiles

Furthermore, obesity negatively affects bone health, elevating the likelihood of osteoarthritis and fractures [5], and it can lead to reproductive issues like polycystic ovary syndrome in women and reduced sperm quality in men [6]

Beyond the reduction in energy intake, co-agonism seems to be able to affect food choice, favoring the consumption of healthy nutrients, how documented in experiments on mice and rats (67)

adults with overweight or obesity who initiated GLP-1 therapy between 2019 and 2024

This article explores evidence-based approaches to managing fatigue during GLP-1 therapy whilst ensuring safe, effective treatment outcomes