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The practical consequence is that subcutaneous injection delivers a known, measurable bolus into the interstitial space where enzymatic degradation begins, but systemic levels are achieved before complete local degradation

Dynamic imaging was performed at 0, 2, 12, 16, 20, 32, and 48 h post-application to monitor hydrogel distribution

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This new paradigm inevitably recalls the concept of intelligent adaptation, promoting design actions built based on natural languages typical of artificial intelligence (AI)