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The FDA-approved prescribing information for semaglutide does not list hepatotoxicity as a recognized adverse effect, and large-scale clinical trials have not demonstrated an increased risk of liver injury compared to placebo or other diabetes medications

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Seek immediate medical attention if you experience: bloody or black stools, severe abdominal pain, signs of significant dehydration (no urine output for 8+ hours, rapid heart rate, confusion), fever above 101F (38.3C), or diarrhea lasting more than 7 consecutive days without improvement

This was a knowledge-based design approach that deconstructed tirzepatide to evaluate its receptor binding and signaling properties