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Why Rapid Degradation Matters The 2-3 minute half-life of GLP-1 created by DPP-4 enzyme activity creates a fundamental challenge for metabolic health

One study on semaglutide reported an average 6-months weight loss of approximately 11.5 kg (roughly 10%15% of baseline weight) and observed a high proportion of improvement in menstrual cycles (39)

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"While this clearly shows an increased risk, 3.3% is still a very low rate of incidence," he said