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Zitka O, Skalickova S, Gumulec J, Masarik M, Adam V, Hubalek J, Trnkova L, Kruseova J, Eckschlager T, Kizek R

PubMed 40861576

Common Mild Side Effects These typically appear during the first few weeks of use: Increased hunger Especially with Ipamorelin due to ghrelin receptor stimulation Mild water retention Often resolves after the body adjusts Tingling or numbness Usually in fingers or hands (transient) Lightheadedness More common with higher doses or low-carb diets Most of these effects are dose-dependent and subside within a week or two

So, while you may be interested in taking a so-called natural GLP-1 supplement, youre unlikely to see a major impact on your weight at least, not nearly at the level that youd see if you took a GLP-1 receptor agonist medication

We also performed Sirius Red staining and, as depicted in Fig