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2021 Jun 18;4(8):e202000906

Noticeable improvement in skin hydration and softness Reduction in redness and skin sensitivity Barrier proteins beginning to strengthen Subtle "glow from within" that precedes visible changes Reactive or damaged skin shows the fastest early response By weeks 34, the first visible changes become apparent

In addition, mutations in ALDH7A1 in the lysine degradation pathway can also cause epilepsy that responds to P5P supplementation.[ref] Regulation of active B6: The cellular levels of P5P are fairly tightly regulated in the body with feedback loops and mechanisms in place

10.1111/j.1749-6632.2000.tb06651.x Ann NY Acad Sci

PMID 21295087