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FIGURE 1 Drug abuse effects on metabolism and epigenetics The metabolic syndrome is a collection of metabolic abnormalities, including hyperinsulinemia, hypertension, dyslipidaemia, and abdominal obesity, and may be triggered by initial discrepancies at the cellular level in critical metabolic pathways

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Clinical trials of brand-name tirzepatide showed average weight loss of 20-22%, with some patients losing over 25% of body weight

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(In contrast, traditional antidepressants require a daily dose and can take several weeks to take effect.) It must be said that psychedelics, psilocybin included, have a complicated history, and their potential for mental health treatment is still being explored (check out our special issue for some myth-busting and breakdowns of the science)