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17 (2006): 20032017, 10.1001/jama.295.17.2003

doi: 10.1136/ard.2010.140145

This finding was further validated by the absence of blood glucose changes in wild-type mice following the administration of exendin 2029 at effective doses, in contrast with the hypoglycemic effect observed with exendin-4

The following framework outlines how tirzepatide's dual mechanism compares to single-pathway GLP-1 agonists and how these differences may affect clinical response

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