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A 2024 randomized controlled trial involving 60 women aged 4065 applied a 0.1% GHK-Cu cream twice daily for twelve weeks and reported a 31% reduction in wrinkles by imaging analysis, along with 28% improved skin elasticity relative to placebo and a 15.6% increase in collagen density measured by ultrasound

These changes, whilst statistically significant in some analyses, were generally modest in magnitude

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Reapply sunscreen every 2 hours: Especially if you're sweating, spending long periods of time outside, or wearing makeup (reapply with SPF sprays or powder)

To avoid or minimize these effects, the medications are started at a low dose and then ramped up slowly over a few months