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Objective markers for considering a return to tirzepatide include sustained weight regain exceeding 5% of your body weight over 3 or more months at maximum semaglutide dose, HbA1c increase exceeding 0.5% above your tirzepatide baseline after 6 months on semaglutide, and persistent side effects that do not resolve after 12 weeks at a stable semaglutide dose

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Studies showed that semaglutide reduces appetite, helping patients achieve significant weight loss while maintaining healthier blood sugar levels