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Factor #1: Weight loss restores ovulation (sometimes very quickly) The mechanism works like this: Excess body fat produces estrogen and disrupts normal ovulation, while fat cells also produce inflammatory compounds that interfere with reproductive hormones

Regarding their metabolic effects, the combination of a GLP-1RA and a SGLT2i significantly reduces HbA1c level, body weight, and SBP, with an additive effect on weight loss and SBP but not on HbA1c [35, 57,58,59]

those with personal/family history of thyroid cancer or pancreatitis should avoid GLP-1 agonists