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the term "human as used herein in connection with antibody molecules and binding proteins first refers to antibodies and binding proteins having variable regions (e.g., V H , VL, CDR or FR regions) and, optionally, constant antibody regions, isolated or derived from a human repertoire or derived from or corresponding to sequences found in humans, e.g., in the human germline or somatic cells

The flagship trial STEP-1 (published in NEJM , 2021) found a mean weight reduction of ~14.9% of body weight with semaglutide 2.4 mg vs ~2.4% with placebo over 68 weeks ( [12] )