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The Science: How the Three Peptides Work Together Retatrutide: The Triple Agonist Retatrutide (LY3437943) is a novel triple agonist peptide that simultaneously activates GLP-1, GIP, and glucagon receptors a first-in-class mechanism among research peptides

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By methylating and removing nicotinamide, NNMT effectively drains NAD+ precursor availability, leading to reduced intracellular NAD+ levels

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