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NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)

Alembic Pharmaceuticals Limited Boehringer Ingelheim Sources Primary Research Interviews: Endocrinologists and diabetologists Pharmacy benefit manager (PBM) formulary leads Brand and medical affairs at GLP-1 / DPP-4 manufacturers Diabetes educators Databases: IQVIA MIDAS Symphony Health PHAST Evaluate Pharma Citeline (Trialtrove) Magazines: Pharmaceutical Executive FiercePharma Endocrine News Diabetes Self-Management Journals: The Lancet Diabetes & Endocrinology Diabetes Care (ADA) Diabetologia (EASD) The New England Journal of Medicine Newspapers: The Wall Street Journal Financial Times Reuters The New York Times Associations: American Diabetes Association (ADA) European Association for the Study of Diabetes (EASD) International Diabetes Federation (IDF) Endocrine Society Public Domain Sources: U.S

The dominant features were psychological rather than physicaldeep anhedonia, loss of interest in things that had always mattered to him, passive thoughts of deathand those are not well explained by a smaller appetite or a few lost kilograms

10.1016/j.bbrc.2004.09.220 Biochem Biophys Res Commun

Evaluating damages requires thorough documentation to build a comprehensive picture of the familys hardships and ongoing needs