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75 A small controlled trial with 23 participants suffering from chronic tinnitus found tailor-made notched music training reduced activity in auditory brain regions and tinnitus loudness more effectively than placebo music training (with a varying notch in frequency range) or no treatment after six months and one year

The 2024 NICE guideline on B12 deficiency in over-16s is built around identifying and treating the cause, not just topping up the number

ISBN 978-1-135-92841-4

The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications

Only a provider can confirm a deficiency, usually with a simple blood test