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The mechanism is likely related to the metabolic changes, reduced caloric intake combined with the body adjusting to higher drug levels

[PubMed: 9311952] 28

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Recently, McDonald and colleagues revealed that frequent mistranslation events involving a shift from serine to either proline or arginine have distinct effects: serineto-proline substitution reduces the ability of polypeptide chains to bind HSP70s, whereas serineto-arginine substitution prevents misfolded nascent proteins from being denatured and degraded (McDonald et al., 2025)