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While familial AD, a less prevalent form, is driven by genetic mutations affecting $A\beta$ metabolism, most sporadic AD cases are attributed to inefficient A clearance (Figure 2)

During the same period, population serum vitamin B-12 concentrations did not change (21)

The taurine transporter: mechanisms of regulation

Although GSH supplementation partially increased viability in both groups, koSLC25A39 cells exhibited persistently reduced viability compared to controls, indicating that exogenous GSH could not fully rescue the viability deficit caused by loss of the mitochondrial inner membrane GSH transporter SLC25A39 (Fig