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A total of 85 differentially expressed metabolites are identified, including amino acids, organic acids, and their derivatives, many of which act as substrates or intermediates in various metabolic processes

The formation of metal-flavonoid complexes significantly enhances their bioavailability, positioning these compounds as promising candidates for next-generation therapeutics ( Ehretia tinifolia extract (ETME) counteracts this response by activating the protective Nrf2/HO-1 pathway while suppressing NF-B/MAPK-mediated inflammation

Their integration with hybrid nanostructures, targeted ligands, and stimuli-responsive systems define the next-generation of personalised nanomedicine