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Specific variants in the GLP1R gene (such as rs6923761) influence how strongly your GLP-1 receptors respond to semaglutide, which directly impacts nausea intensity and onset timing

A small number of GHR antagonists have been used in an oncology settings in preclinical studies and the growth-inhibiting effects have been reported in colon, breast, and meningioma tumor xenografts, which suggested that GHR antagonism as a monotherapy is efficient in some tumor types (Friend, 2001