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However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

Functionally, EP300 was shown to directly catalyze the lactylation of key regulatory proteins (such as the RNA-binding protein FUS)

Ethics statement This systematic review and meta-analysis did not involve human subjects or animals, so ethical approval was not required

Recent advances in protein engineering and biotechnological applications of glutathione transferases

Stefan Phlmann and Dr