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"In my practice, we go down in dose gradually, the same as we go up, in order to monitor changes and maintain control," she says

(2025) doi: 10.1001/jamapsychiatry.2024.4789 Summary Keywords alcohol use, All of Us cohort, cocaine dependence, drug repurposing, GLP-1 receptor agonists, nicotine dependence, opioid use, substance use disorders Citation Abegaz TM, Ahmed M, Bhagavathula AS and Frietze G (2026) Association between GLP-1 receptor agonist use and substance use disorders among individuals with type 2 diabetes or obesity: a nested case-control study in the All of Us research program

This is a small adjustment that can make a real difference in how your body feels during your runs

Another option, Zepbound, is a dual GIP/GLP-1 agonist engaging two hormones for superior weight loss results

Talk to your healthcare provider first