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10.1039/c8en01427b 32 Gonzalez-ReyM.BebiannoM

31 Intranasal administration of Semax at 16 mg/kg in healthy adults improved decision-making, work site performance, mental acuity, short-term memory, and attention span, with results lasting up to 24 hours

Intracellularly, CHAC1 enzymatically degrades GSH into 5-oxoproline and Cys-Gly, acting as a pro-ferroptotic execution signal by accelerating GSH exhaustion 151

Integrating our data with existing single-nuclear sequencing information, we found subpopulations of cortical SST INs that express signalling genes linked to cognitive resilience, whilst glutamatergic neurons were enriched for cytoskeletal genes associated with frailty 14,20