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Amino acid substitution at position 8 allows semaglutide to resist degradation by dipeptidyl peptidase-4

Additional information Peer review information Nature thanks Doryen Bubeck, Dave DAlessio, Nita R

In particular, interactions with Y220 and W297, residues known to play a key role in stabilizing active receptor conformations, suggest that the compound is able to adopt a binding mode compatible with receptor activation

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Healthy fats from olive oil, avocado, and nuts work well toothey digest slowly and pair naturally with protein and vegetables