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1 Your team will usually continue the medication only if, after 6 months, your HbA1c (a measure of your average blood sugar over the past 2 to 3 months) has fallen by at least 1% and youve lost at least 3% of your body weight

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This lack of protein ends up leading to less collagen and elastin being produced in the skin. These medications also tend to cause loss of bone density as well as muscle mass, he adds

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*My tweet from March 1, 2026, before these new data were published By contrast, lean body mass typically contributes ~25% during weight loss driven primarily by lifestyle interventions