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Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

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These findings support the notion that, similar to the development of peripheral opioid receptor antagonists, developing therapeutic targeting specific brain regions is one of several avenues that warrant exploration for patients unresponsive to current therapies

For mitochondrial ROS detection, the cells were stained with 5 g/mL MitoSox dye (Thermo Scientific, Waltham, MA, USA) at 37 C for 15 min, followed by three PBS washes

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