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The MHRA regulates all injectable B12 products in the UK, ensuring quality and safety standards

A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data

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Evidence for bodybuilding-specific outcomes, such as lean mass gain or fat loss in healthy, non-HIV populations, is comparatively thin and largely extrapolated rather than directly studied in controlled trials

After three weeks of daily injections, he felt he could better focus, remain calm and retain information