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A cornerstone benefit of GLP-1 medications is their ability to naturally and effectively improve blood sugar control

Similarly, the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) [47] and the Study of Heart and Kidney Protection with Empagliflozin (EMPA-KIDNEY) [48] trials expanded inclusion beyond diabetes mellitus, showing that dapagliflozin and empagliflozin significantly reduced the risk of kidney outcomes, with consistent benefits across a wide range of eGFR and albuminuria

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Topiramate, a carbonic anhydrase inhibitor, promotes a decrease in urinary citrate excretion, increase in urinary pH, and hypercalciuria, leading to an increased risk of stone formation