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Osterstock G, Escobar P, Mitutsova V, Gouty-Colomer LA, Fontanaud P, Molino F, et al

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Results Genetically predicted l-carnitine was nominally associated with higher risk of CAD overall (OR 1.07 per standard deviation (SD) increase in l-carnitine, 95% CI 1.02 to 1.11) and in men (OR 1.09, 95% CI 1.02 to 1.16) but had a null association in women (OR 1.00, 95% CI 0.92 to 1.09)

By activating both receptor systems, tirzepatide appears to produce greater weight loss than GLP1 agonists alone

About five years later, novo nordisk introduced to simulate human glp-1 lalu peptide (Victoza)