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Lifestyle interventions and medications such as metformin have been proposed to reduce risk but remain limited in efficacy

Split into two doses if using higher amounts

washout Timeline 1: Immediate switch (most common) Day 0: Last Wegovy injection Day 7: First Zepbound injection (2.5 mg or higher per provider instruction) Day 14: Second Zepbound injection Weeks 5, 9, 13, etc.: Dose increases per titration schedule This approach maintains continuous GLP-1 receptor agonism

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The recommended schedule from clinical trials is: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly Week 21+: 15 mg once weekly (maximum dose) Not everyone follows this exact schedule