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Approximately 70% of GLP-1 users achieve clinically significant weight loss (5% body weight reduction), while 30% experience modest or delayed responses

Diabetes Ther 16 , 22372256 (2025)

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Weight loss results from clinical trials: Adults lost nearly 15% of their starting body weight on average Adolescents lost almost 15% of their starting body weight Wegovy HD (higher dose) produced 19% average weight loss Cardiovascular benefit: The SELECT trial showed a 20% reduction in MACE risk compared to placebo