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Roglic G, Unwin N, Bennett PH, et al
J Neuroimmune Pharmacol 9(5):690702
Rare but notable: repeated use can occasionally cause focal skin darkening (hyperpigmentation), particularly on the face
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound) in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity
Unlike statins, which can cause myopathy through effects on muscle cell membranes and mitochondrial function, GLP-1 agonists do not have a known direct myotoxic mechanism
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