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Treating major depressive episodes with antidepressants can induce or worsen metabolic syndrome: Results of the METADAP cohort

Phase 2 clinical trial data published in the New England Journal of Medicine in 2023 demonstrated substantial mean reductions in body weight in some participants exceeding 20% over 48 weeks alongside improvements in glycaemic control and cardiometabolic markers

Compared to 47 pounds in the diet-only control group

In contrast, short-acting GLP-1RAs, such as lixisenatide, require more frequent dosing due to shorter half-lives, resulting in intermittent receptor stimulation that may reduce the risk of diarrhea

I am extremely happy with the outcome and the way I look