Rather than extending the interval between injections, a more effective approach is working with your provider to slow the dose escalation, use supportive medications for nausea, or adjust injection timing
Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years
The mechanism of action of tirzepatidetargeting GIP and GLP-1 receptors to regulate glucose metabolism and appetitehas no known direct effect on iron metabolism or ferritin synthesis pathways
You can get a 2.5 mg Zepbound vial for $299 per month, 5 mg for $399 per month, and 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg vials for $449 per month
It affects approximately 12% of the global population, with onset typically in late adolescence or early adulthood ( Among the most clinically significant medical comorbidities is metabolic syndrome (MetS), a cluster of interrelated cardiometabolic abnormalities that includes abdominal obesity, hyperglycemia, elevated blood pressure, hypertriglyceridemia, and reduced HDL cholesterol (6, 7)
