As absorption is reduced, body stores become low and a deficiency occurs Underlying diseases most commonly include: IBD (inflammatory bowel disease) Intestinal cancer (especially small cell lymphoma) Liver disease Pancreatitis and other pancreatic diseases Symptoms of low B12 levels Typically found in middle-aged or older cats that present with: Weight loss Diarrhea Vomiting Anorexia Thickened intestines In humans, B12 deficiency may also be associated with dementia, cardiovascular disease, and a certain type of anemia, although these are not specifically recognized problems in cats
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Although these findings may a priori not be applicable for a proper exposure assessment in other countries, it seems plausible to estimate that normal daily intake rates via Western-style diets (not by enriched products) may not exceed 200 mg/d
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[3] Studies suggest that oral and topical formulations can modulate these pathways, but the extent of clinical benefit remains debated
