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On the other hand, certain studies have demonstrated the overexpression of GLP-1R in brain tumors, embryonic tumors, gut and lung neuroendocrine tumors, including other endocrine tumors like Pheochromocytomas, raising concerns that existing GLP-1RAs can contribute to tumor growth in humans (Shilyansky et al., 2025

The side effects were the familiar nausea and sickness, and about 1 in 9 people on the top dose stopped because of them

Human research on this specific endpoint is still limited

Meanwhile, its archrival Eli Lilly has indicated its plans to retain the premium pricing of its brand Mounjaro (tirzepatide), citing the therapys superior efficacy over semaglutide

Enhancing provider education across primary and secondary care is essential to improve early recognition of symptom patterns and reduce normalization of patient complaints